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By Thomas E. Bax and Thomas E. Brown

An experimental animal study using sildenafil citrate to treat erectile dysfunction. The research was funded by the National Institute of Health and supported by the National Institute of Child Health and Human Development and supported by the National Institute of Child Health and Human Development. The study was conducted in the Department of Biotechnology, University of Oxford. The study was approved by the Oxford Human Research Ethics Committee (reference number H0221/12), and the study was performed in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants included in the study.

About Erectile Dysfunction

Erectile dysfunction (ED) is the inability to obtain or maintain an erection sufficient for sexual activity. It can be caused by various factors such as diabetes, cardiovascular disease, psychological issues, or certain medications. Psychological factors and certain medications can also increase the risk of ED.

The prevalence of ED has been estimated to be 25 to 50% by the United States. The World Health Organization estimates that about 1.2 million people in the United States are affected by ED. In the United States, approximately 1 in 10 males aged 15 years and older suffer from ED. The prevalence of ED increases with age.

About ED Medication

In the past few years, sildenafil (Viagra®, Pfizer®) was approved by the FDA and approved for the treatment of erectile dysfunction (ED). The most common brand name of sildenafil citrate is Viagra®. Sildenafil citrate is used to treat erectile dysfunction by increasing blood flow to the penis by relaxing the muscles in the penile arteries and allowing them to widen.

Viagra® is the brand name for sildenafil, sold under the brand name Revatio®. Revatio® is used to treat pulmonary arterial hypertension (PAH) by relaxing the blood vessels in the lungs and improving exercise capacity in patients with PAH.

Sildenafil (Viagra®) is not a controlled substance, so it can only be used under the supervision of a medical professional. The drug is not prescribed to patients with cardiovascular disease or any other health conditions. If a patient experiences sexual activity with Viagra®, they should be instructed to stop the drug immediately and seek medical advice if they experience any of the side effects.

ED can occur in a number of causes. These include:

  • Genital edema (excessive sweating);
  • Penile erection difficulties;
  • Pulmonary arterial hypertension (pulmonary veno-occlusive disease);
  • Pulmonary hypertension due to chronic inflammation of the pulmonary arteries.

The most common side effects of Viagra® include:

  • Headache
  • Flushing
  • Indigestion
  • Stuffy or runny nose
  • Muscle pain, back pain
  • Dizziness

Sildenafil (Viagra®) has the following adverse effects:

  • Sudden vision loss, blurred vision, or color vision problems;
  • Sudden hearing loss;
  • Sudden vision changes.

Sildenafil (Viagra®) can cause:

  • Sudden hearing loss
  • Sudden hearing decrease or loss in hearing
  • Sudden vision loss;
  • Sudden loss of hearing;
  • Sudden numbness or weakness of the hands or feet.

The following side effects are uncommon:

  • Sudden vision loss.

These rare side effects are not likely to occur. If you experience any of these side effects, please report them to the doctor or pharmacy at your nearest Oxford Pharmacy.

Patients taking sildenafil can be prescribed a stronger, longer-acting ED drug, which could help improve their sexual activity.

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Last updated 14 September 2023

On 14 March 2023, the UK Medicines regulator approved an application to reclassify the erectile dysfunction medication Cialis. When marketed asCialis Together(tadalafil 10mg), it will be a ‘P’ (pharmacy) medication, and so available ‘over the counter’ in pharmacies – see. This follows the 2018, ‘P’ classification of (sildenafil 50mg) which has been available OTC, without a prescription, since then.

This decision is good news for men’s health …. Erectile dysfunction can be a debilitating condition, so it’s important men feel they have fast access to quality and legitimate care

Dr Laura Squire, MHRA’s Chief Officer for Healthcare, Quality and Access

Unfortunately, there is a strong black market in the UK for ED medicines, which are often unlicensed or counterfeit. UK Border Force and the MHRA seize millions of pounds of these fake products from criminals annually. This new classification of tadalafil 10mg will enable men who suffer from ED to obtain it safely from a local pharmacy.

Sanofi, the drug manufacturer, is expected to launch Cialis Together later in 2023. Cialis Together will be available to purchase in pharmacies without a prescription by men over 18 with erectile dysfunction. Cialis Together tablets will contain 10mg tadalafil and the maximum pack size will be 8 tablets. Other doses and pack sizes of Cialis and tadalafil will still be available on prescription through doctors and specially trained pharmacists. Before purchase in a pharmacy there must be an assessment with a pharmacist, who will check that Cialis Together is appropriate and safe, or whether consultation with a GP is necessary.

What does this mean for patients?

Men suffering with ED will have another treatment option with the convenience of purchasing it in their local pharmacy, including pharmacies found inside supermarkets (eg. Tesco, Asda, Sainsbury’s). The pharmacist will ask some health questions, may check blood pressure, and will advise on treatment with Cialis Together or Viagra Connect, or the need to consult a GP. Pharmacies usually have a private room for such discussions.

Cialis Together is a 10mg tadalafil product for use at least 30 minutes prior to anticipated sexual activity. Its effects can last. It is not recommended for daily use. The maximum recommended dose of Cialis Together will be one tablet in 24 hours. Prescription Cialis and tadalafil will still be available at different doses.

Dr Fox welcomes the wider access to ED medication for men that Cialis Together classified as a ‘P’ OTC medication will provide. We at Dr Fox are aware of the difficulties men have in discussing ED with their GPs and in accessing ED medication. We know that Cialis is effective and safe for most men and this change provides another option for obtaining ED treatment. Pharmacists are health professionals who are able to give ED advice but they will also know when to refer men who would benefit from a doctor’s assessment. ‘P’ medicines can also be supplied on prescription, and we will offer Cialis Together, when available, alongside our other competitively priced ED products.

Dr Claire Pugh, Dr Fox Medical Director

Categories of medicine

In the UK have 3 categories:

  • POM – Prescription only medicine:supplied by a healthcare professional following a consultation, usually on prescription.
  • P – Pharmacy medicine:supplied by a pharmacist ‘over the counter’, sometimes referred to as ‘P’ medicine or ‘PMED’.
  • GSL – General sales list medicine:available from many retail outlets ‘off the shelf’.
As with the list of things in - -, and, the Cialis Together list of things in is an Openel list. This category is available on the Medical Specials website and will be. There’s a.

Cialis Together inDoctorss

Cialis Together will be available on. It is a list of the actinical ingredients, which are listed in product information leaflets. ProductWARNINGS For Cialis Together products,, and. Men with certain heart or (QT prolongation) conditions (e.g.

Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

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Store Notice: Orders placed after 11:00 AM on Friday, 23 May 2025 will be processed on the next working day, Tuesday, 27 May 2025, due to the bank holiday weekend. Thank you for your understanding.

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